Research Interests: Molecular mechanisms by which diet modulates host-microbiome interaction, e.g., aryl hydrocarbon signaling cascades and genomic responses in relation to stem cell biology; noninvasive biomarkers using host exfoliomics and gut microbial metagenomics; membrane therapy and proteolipid nanoclustering; dietary interactions, colon cancer and chronic inflammation. Chapkin Laboratory.
Obesity & postmenopausal breast cancer: Studying the relationship between obesity, menopause, weight gain and inflammation, and their combined effects on (1) breast cancer development/progression and (2) metabolic health.
Develop educational strategies targeting nutrition education for medical students and physicians; examine anti-obesity policies targeting childhood obesity; perform school plate waste studies; develop/test anti-obesity food product formulations.
Food Technology, Extrusion Processes, Cereals and Snacks food extrusion, Oil Seed Processing, Recycling of Food By Products, Ethnic and Religious Food, Food Product Development, Feeds and Pet Food Extrusion, Aquaculture Feed Processing, Texturization of Vegetable Protein.
Dr. Sun is an expert on “hunger hormone” ghrelin. She generated the first ghrelin knockout mice, and discovered ghrelin’s novel roles in diabetes, thermogenesis and macrophage polarization. Her laboratory uses state-of-the-art tools to study ghrelin in energy sensing, intake and expenditure. Their work suggests that ghrelin might be a promising drug target for obesity, diabetes, aging, inflammation and cancer.
Assessing bioactive compounds in fruits and vegetables, dietary supplements, antioxidant fruit juices and other foods to define their role in prevention of chronic diseases and the protection of health in an integrative, translational research approach.
Dr. Linglin Xie, research has been focused on understanding the molecular basis of obesity and insulin resistance. Her recent study focus is to find out if and how different maternal diet intervention before pregnancy would prevent the downstream offspring. She is also interested in understanding how maternal obesity or diabetes increase the risk of congenital heart defects of the baby.