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Erin Giles

Giles, Erin
Erin Giles
Assistant Professor
Office:
214A Cater-Mattil
Email:
Phone:
9794581849
Undergraduate Education
B.Sc. in Bio-Medical Science (Honours)
University of Guelph, Ontario, Canada, 2000
Graduate Education
Ph.D.in Medical Science, McMaster University, Hamilton, Ontario, Canada, 2007
Postdoctoral Fellowship, Division of Endocrinology, Diabetes & Metabolism, Anschutz Health and Wellness Center, University of Colorado School of Medicine, Aurora, Colorado
Awards
2015-Outstanding Post-Doctoral Fellow, University of Colorado Nutrition Obesity Research Center
2014-Colorado Center for Women’s Health Research - Junior Faculty Research Development Award
2014-Postdoctoral Fellow of the Year, Division of Endocrinology, Diabetes, & Metabolism, University of Colorado School of Medicine
2014-Top Abstract, The Obesity Society – Obesity & Cancer Section
2014-Travel Award - Integrating Resistant Starch, Microbiome, and Disease Risk Reduction Symposium
2013-Early Career Travel Award, Endocrine Society Annual Meeting
2012-Research Recognition Award, American Physiological Society, Integrative Biology of Exercise IV Meeting
2012-Winning Poster, University of Colorado Postdoctoral Research Day
2010-Colorado Nutrition and Obesity Research Center Pilot Award
2010-American Institute for Cancer Research Fellowship
2009-Thorkildensen Research Fellowship
2009-Early Career Investigator Travel Award, Kern Aspen Lipid Conference
2009-Travel Award, FASEB Summer Research Conference - The Physiological Basis for Obesity Therapeutics
2008-University of Colorado Denver, School of Medicine Research Day 1st place - Postdoctoral Fellows Category
2006-McMaster University Department of Oncology Residents Research Day 1st place (oral)
2003-Canadian Breast Cancer Foundation Research Fellowship
2003-Travel Award, Gordon Research Conference - Insulin-Like Growth Factors in Physiology & Disease, Scholar
2001-2003 -Ontario Graduate Scholarship
2000-2001-Graduate Scholarship, McMaster University
1999-Undergraduate Research Fellowship Award, University of Guelph

Research Interest

I am currently building a research program that uses an integrative, translational approach to understand the mechanisms by which obesity promotes postmenopausal breast cancers. My work focuses on understanding how the obese microenvironment, when combined with the metabolic and hormonal changes associated with menopause, promote tumor development, survival, and growth.  In parallel, I am investigating the role of adipose tissue inflammation in the development of metabolic disease after menopause. My hope is that the knowledge gained from studying the ‘normal’ adipose and breast environments during menopause will also help us understand the changes that occur to create a tumor-promoting environment in the breast of obese women during this same window of time.

Publications

  1. Giles, ED, Jindal, S, Wellberg, EA, Schedin, T, Anderson, SM, Thor, AD et al.. Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Res. 2018;20 (1):50. doi: 10.1186/s13058-018-0974-2. PubMed PMID:29898754 PubMed Central PMC6000949.
  2. Wellberg, EA, Checkley, LA, Giles, ED, Johnson, SJ, Oljira, R, Wahdan-Alaswad, R et al.. The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer. Horm Cancer. 2017;8 (5-6):269-285. doi: 10.1007/s12672-017-0302-9. PubMed PMID:28741260 PubMed Central PMC6022404.
  3. Sherk, VD, Jackman, MR, Giles, ED, Higgins, JA, Foright, RM, Presby, DM et al.. Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function. Physiol Rep. 2017;5 (10):. doi: 10.14814/phy2.13272. PubMed PMID:28533263 PubMed Central PMC5449558.
  4. Checkley, LA, Rudolph, MC, Wellberg, EA, Giles, ED, Wahdan-Alaswad, RS, Houck, JA et al.. Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo. Cancer Prev Res (Phila). 2017;10 (3):198-207. doi: 10.1158/1940-6207.CAPR-16-0211-T. PubMed PMID:28154203 PubMed Central PMC5405741.
  5. Sherk, VD, Carpenter, RD, Giles, ED, Higgins, JA, Oljira, RM, Johnson, GC et al.. Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training. Med Sci Sports Exerc. 2017;49 (5):888-895. doi: 10.1249/MSS.0000000000001194. PubMed PMID:28079706 PubMed Central PMC5392148.
  6. Giles, ED, Jackman, MR, MacLean, PS. Modeling Diet-Induced Obesity with Obesity-Prone Rats: Implications for Studies in Females. Front Nutr. 2016;3 :50. doi: 10.3389/fnut.2016.00050. PubMed PMID:27933296 PubMed Central PMC5121240.
  7. Giles, ED, Hagman, J, Pan, Z, MacLean, PS, Higgins, JA. Weight restoration on a high carbohydrate refeeding diet promotes rapid weight regain and hepatic lipid accumulation in female anorexic rats. Nutr Metab (Lond). 2016;13 :18. doi: 10.1186/s12986-016-0077-y. PubMed PMID:26937246 PubMed Central PMC4773993.
  8. Giles, ED, Steig, AJ, Jackman, MR, Higgins, JA, Johnson, GC, Lindstrom, RC et al.. Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss. Front Physiol. 2016;7 :32. doi: 10.3389/fphys.2016.00032. PubMed PMID:26903882 PubMed Central PMC4748045.
  9. Martinson, HA, Lyons, TR, Giles, ED, Borges, VF, Schedin, P. Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention. Exp. Cell Res. 2013;319 (11):1671-8. doi: 10.1016/j.yexcr.2013.04.018. PubMed PMID:23664839 PubMed Central PMC3980135.
  10. Giles, ED, Wellberg, EA, Astling, DP, Anderson, SM, Thor, AD, Jindal, S et al.. Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer Res. 2012;72 (24):6490-501. doi: 10.1158/0008-5472.CAN-12-1653. PubMed PMID:23222299 PubMed Central PMC4010325.
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