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Shaodong Guo

Guo, Shaodong
Shaodong Guo
Associate Professor
123A Cater-Mattil
Undergraduate Education
Huazhong Agricultural University, 1989
B.S. in Agronomy
Graduate Education
Peking University, 1995
Ph.D. in Physiology
2015- American Diabetes Association Research Excellent Thomas R Lee Award
2015- American Diabetes Association Career Development Award
2007- American Diabetes Association Junior Faculty Award
1999- Travel Award of American 81st Annual Meeting of Endocrine Society
1999- Young Investigator Award, National Natural Science Foundation of China
1999- Young Investigator Award, Institute of Genetics and Developmental Biology of Chinese Academy of Sciences, Beijing, China
1995- Guanghua Scholarship for outstanding Ph.D. Student Award, Peking University, Beijing, China
Courses Taught
NUTR 481: Nutrition Seminar
MSCI 612: Current Topics in Cell Signaling
MSCI 601: Cell Biology
MPHY 631: Cardiovascular Science
MPHY 632: Cardiovascular Pathology

Research Interest

The long-term goal of our research is to study the molecular mechanisms of insulin signal transduction, insulin resistance and associated cardiovascular dysfunction, aiming at nutritional and therapeutic intervention for control of metabolic and cardiovascular disorders. My laboratory is focused on the study of cellular signaling and gene transcriptional regulation of metabolic homeostasis that are governed by the PI3K→Akt→FoxO pathway, with the hope of understanding how dysregulation of this pathway in insulin/IGF-1 action causes liver damage, cardiovascular dysfunction, and pancreatic beta cell failure, resulting in diabetes, obesity, and organ failure. Our research encompasses several areas. Firstly, we will decode the mechanism of insulin resistance and associated cardiovascular dysfunction. It is known that excess nutrients cause or accelerate insulin resistance, investigating how nutrient-mediated signaling activates intracellular mediators that attenuate the insulin→IRS→Akt→FoxO signaling pathway will provide a powerful platform for nutritional and therapeutic intervention for the treatment of diabetes and cardiovascular disorders. The discovery of bioactive compounds, functional food, peptides, nucleotides, or stem cells that increase gene expression of IRS or promote FoxO phosphorylation and ubiquitination will promote drug development and provide new insights on nutritional and therapeutic targets. Secondly, we will define the roles of FoxO proteins in insulin signaling and insulin resistance through creation of cell lines and animal models in which FoxO is either eliminated by a genetic “knock-out” or increased by overexpression. This will also include studies utilizing the technique of tissue specific gene inactivation or activation (knock-in) to determine the role of FoxO in various tissues, including classic and non-classic target tissues for insulin action, such as liver and heart. Lastly, we will explore the novel players mediating insulin actions, as well as other hormones including glucagon, in control of energy metabolism and survival. We have taken advantage of IRS and FoxO genetically engineered mouse and cell models with analyses in genomics, proteomics, and metabolomics, to better define the physiological connections between metabolic regulation and FoxO in intracellular signaling networks.


  1. Yan, H, Yang, W, Zhou, F, Li, X, Pan, Q, Shen, Z et al.. Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1. Diabetes. 2018; :. doi: 10.2337/db18-0638. PubMed PMID:30487265 .
Search PubMed
  1. Zhang, K, Li L, Qi Y, Zhu X, Gan B, DePinho R, Averitt T, Guo S. Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice. For editorial preview see page 549-510. Endocrinology 153 (2): 631-646, 2012.. PMID:22147007.
  2. Messmer-Blust AF, Philbrick MJ, Guo S, Wu J, He P, Guo S, Li J. RTEF-1 Attenuates Blood Glucose Levels by Regulating Insulin-Like Growth Factor Binding Protein-1 in the Endothelium. Circulation Research 111:991-1001, 2012. For editorial see page 951-953. PMID:22843786.
  3. Guo S. Molecular Basis of Insulin Resistance: The role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications. Drug Discovery Today: Disease Mechanisms. 10(2): e27-e33, 2013. PMID:24015152.
  4. Qi Y, Zhu Q, Xu Z, Thomas C, Kumar R, Feng H, Dostal D, White MF, Baker K, Guo S. Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and is Controlled by p38α MAPK During Insulin Resistance. (Highlighted on Faculty of 1000). Diabetes 62:3887-3900, 2013. PMID:24015152.
  5. Ma J, Zhang L, Tipton AR, Wu J, Qi Y, Messmer-Blust A, Philbrick M, Liu ST, Liu H, Li J, Guo S. Structural and Functional Analysis of the Related Transcriptional Enhancer Factor-1 (RTEF-1) and Nuclear Factor Kappa B (NF-κB) Interaction. American Journal of Physiology-Heart and Circulatory Physiology 306: H233-H242, 2014. PMID: 24213609.
  6. Guo S. Insulin Signaling, Resistance, and the Metabolic Syndrome: Insights from mouse models to disease mechanisms. J. Endocrinology 220(2):T1-23, 2014. PMID: 24281010.
  7. Qi, Y, Zhang, K, Xu, Z, Yong, Q, Wu, Y, Kumar, R, Baker, K, Zhu, Q, Chen, S, Guo, S. Novel Mechanism of Blood Pressure Regulation by Foxo1-Mediated Transcriptional Control of Hepatic Angiotensinogen. Hypertension 64 (5): 1131-1140, 2014. PMID: 25069665
  8. Qi, Y, Zhu, Q, Qi, Y, Zhang, K, Thomas, C, Wu, Y, Kumar, R, Baker, K, Xu, Z, Chen, S, Guo, S. Activation of Foxo1 by Insulin Resistance Promotes Cardiac Dysfunction and β-Myosin Heavy Chain Gene Expression. Circulation: Heart Failure (8):198-208, 2015. PMID:25477432.
  9. Xie, W, Wang, L, Dai, Q, Qi, Y, Hu, F, Guo, S*, Zhang, K* (2015). Activation of AMPK Restricts Coxsackievirus B3 Replication by Inhibiting Lipid Accumulation. Journal of Molecular and Cellular Cardiology 85:155-167, 2015. *co-corresponding author
  10. Drosatos, K, Pollak, M, Pol, C, Ntziachristos,P, Willecke, F, Valenti, M, Trent, C, Hu, Y, Guo, S, Aifantis, I, Goldberg, I (2015). Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function. Circulation Research (online published Nov. 16, 2015)
  11. Qi, Y, Guo, X, and Guo, S. (2016) Insulin Resistance in Obesity. In: Metabolic Syndrome: A Comprehensive Textbook, pages 479-504, 1st edition, edited by Rexford Ahima. Springer International Publishing, Inc.