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Chaodong Wu

Wu , Chaodong
Chaodong Wu
Associate Professor and Faculty Fellow
217A Cater-Mattil
Undergraduate Education
Hubei University of Chinese Medicine (Wuhan), China. MD, Medicine, 1992
Graduate Education
Tongji Medical University (Wuhan), China. Master of Medical Science, 1995
Beijing Medical University, China. PhD in Medical Science, 1998
Junior Faculty Award, American Diabetes Association, 2010
Research Award, Minnesota Medical Foundation, 2004
Travel Award, Dept. of BMBB, the University of Minnesota, 2001
Pilot & Feasibility Research Award, Minnesota Obesity Center, 2002, 2005
Travel Award, The Center for Diabetes Research, University of Minnesota, 2001
Courses Taught
NUTR 470: Nutrition and Physiological Chemistry
NUTR 681: Nutrition Seminar

Research Interest

The long-term goal of Dr. Wu’s research program is to elucidate the mechanisms underlying the pathogenesis of obesity and overnutrition-associated metabolic diseases including insulin resistance, diabetes, and fatty liver disease so that novel dietary and/or pharmacological approaches can be developed for preventing and/or treating metabolic diseases. Using molecular, cellular, and integrative approaches, the Wu lab is focused on investigating the interaction between metabolism and inflammation.


Research Area

Obesity, insulin resistance, diabetes, and fatty liver disease


  1. Wu, N, Meng, F, Zhou, T, Venter, J, Giang, TK, Kyritsi, K et al.. The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor (TGF)-β1-Mediated Biliary Senescence. Am. J. Pathol. 2018; :. doi: 10.1016/j.ajpath.2018.06.015. PubMed PMID:30036520 .
  2. Zhou, T, Wu, N, Meng, F, Venter, J, Giang, TK, Francis, H et al.. Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes. Lab. Invest. 2018; :. doi: 10.1038/s41374-018-0093-9. PubMed PMID:29977037 .
  3. Wu, N, McDaniel, K, Zhou, T, Ramos-Lorenzo, S, Wu, C, Huang, L et al.. Knockout of microRNA-21 attenuates alcoholic hepatitis through VHL/NF-κB signaling pathway in hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2018; :. doi: 10.1152/ajpgi.00111.2018. PubMed PMID:29848019 .
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